SODIUM NITROPRUSSIDE AND ROAD TO DISASTER
نویسندگان
چکیده
منابع مشابه
Sodium nitroprusside: theory and practice.
Sodium nitroprusside, by a peripheral vasodilator action, is a powerful hypotensive drug. In contrast to established agents, its hypotensive action is accompanied by an unchanged or augmented cardiac output. Intravenous administration of sodium nitroprusside rapidly produces a profound and controllable hypotension. Normotension is swiftly restored by ceasing to infuse the agent, and antidotes a...
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Except when used briefly or at low (< 2 mcg/kg/min) infus ion rates , sodium nitropruss ide gives rise to important quantities of cyanide ion, which can reach toxic, potentially lethal levels (see WARNINGS). The usual dose rate is 0.5 to 10 mcg/kg/min, but infus ion at the maximum dose rate should never las t more than 10 minutes . If blood pressure has not been adequately controlled after 10 m...
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The goal of hyptensive anesthesia is the safe reduction of intraoperative blood loss, thus reducing transfusion risks. Previous hypotensive technics had a narrow margin of safety in that cardiac output was usually reduced in proportion to the degree of induced hypotension. This is in contrast to the results of our study, in which Sodium Nitroprusside was used as the sole hypotensive agent. Ni...
متن کاملThe cerebral response to sodium nitroprusside and trimethaphan controlled hypotension.
THE EFFECTS of altered arterial blood pressure on cerebral blood flow ( CBF ) have been well documented by Lassen 1'2 and Olesen 3 in man, and by Rapela, 4 Waltz ~ and Yashon 6 in dogs. The critical determinants of cerebral blood flow are the cerebral perfusion pressure (CPP) and the cerebrovascular resistance (CVR). The CPP is the difference between the driving force of the mean arterial press...
متن کاملSodium Nitroprusside for Aneurysm Surgery in Pregnancy
A 25-year-old woman in the 7th month of pregnancy was operated upon for a ruptured cerebral aneurysm. Sodium nitroprusside was used to achieve effective controlled hypotension. Signs of foetal distress were transient. Subsequent delivery was spontaneous and uneventful. Development of the child at 2 yr was satisfactory. The various physiological aspects and the action of nitroprusside on both mo...
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ژورنال
عنوان ژورنال: Medical Journal Armed Forces India
سال: 1996
ISSN: 0377-1237
DOI: 10.1016/s0377-1237(17)30894-8